ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 1 of about 2 results

ey0015.10-1 | Aetiology and heterogeneity of type 1 diabetes | ESPEYB15

10.1 TCF7L2 genetic variants contribute to phenotypic heterogeneity of T1DM

MJ Redondo , S Geyer , AK Steck , J Sosenko , M Anderson , P Antinozzi , A Michels , J Wentworth , P Xu , A Pugliese , T1DM TrialNet Study Group

To read the full abstract: Diabetes Care. 2018;41:311-317Some researchers assume that the etiology of T1DM is distinct from that of Type 2 diabetes mellitus. T1DM is characterized by autoimmune phenomena leading to the destruction of pancreatic islets and most importantly of beta-cells. Genetic factors are thought to influence the likelihood of autoimmune phenomena developing into overt autoimmune di...
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ey0015.10-21 | Prevention | ESPEYB15

10.21 Loss of intra-islet heparan sulfate is a highly sensitive marker of T1DM progression in humans

CJ Simeonovic , SK Popp , LM Starrs , DJ Brown , AF Ziolkowski , B Ludwig , SR Bornstein , JD Wilson , A Pugliese , TWH Kay , HE Thomas , T Loudovaris , FJ Choong , C Freeman , CR Parish

To read the full abstract: PLoS One. 2018;13:e0191360Up to now most studies to prevent autoimmune T1DM have focused on directly suppressing the autoimmune response rather than to better understanding the intrinsic requirements for beta cell survival. In this trial intracellular heparan sulfate was investigated as an essential requirement for the survival of beta cells and a marker for beta...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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